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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Narirutin, Cisplatin
Phytochemical Name Narirutin (PubChem CID: 442431 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cisplatin
Adverse Reactions Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug.
Recommendations Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 114
Ref_1
Pair Name Narirutin, Cisplatin
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Ion channel protein
Gene Regulation Down-regulation Expression ANO1 hsa55107
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Down-regulation Expression CCND1 hsa595
Up-regulation Expression CDH1 hsa999
Down-regulation Expression CDH2 hsa1000
Down-regulation Phosphorylation MAP2K7 hsa5609
Down-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Expression VIM hsa7431
In Vitro Model LA-795 Adenocarcinoma of the mouse pulmonary system Mus musculus (Mouse) CVCL_G363
In Vivo Model LA795 cells were inoculated to Balb/c mice (6- to 8-week-old) in the right forelimb. Tumor volumes were measured every 5 day.
Result Based on the significant anticancer effect and high biosafety, naringin has great potential as a functional food in the adjuvant treatment of lung cancer.
03. Reference
No. Title Href
1 Molecular mechanism of ion channel protein TMEM16A regulated by natural product of narirutin for lung cancer adjuvant treatment. Int J Biol Macromol. 2022 Dec 31;223(Pt A):1145-1157. doi: 10.1016/j.ijbiomac.2022.11.123. Click
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